Friday, May 11, 2018, 3:30pm **Note the time**
Location: Exploratory Hall 3301 **Note the location**
Divita Mathur
Naval Research Laboratory
Washington DC
DNA Self-Assembly: A Nanoscale
Building Block for Bottom-up Fabrication
Abstract
The
field of DNA nanotechnology has enabled scientists to realize and
rapidly expand the ability to “build” objects at
the
nanoscale. With the help of a growing repository of DNA self-assembling
tools and strategies, it is possible to create two- and
three-dimensional structures ranging from a few nanometers to
micron-scale in size. The cumulative properties of DNA, particularly
its well-studied structural and physical behavior in response to varied
conditions, its chemical and biological compatibility with a host of
organic and inorganic nanoparticles, and the predictable base pairing
principles have enabled DNA nanotechnology to be widely adopted in many
scientific disciples, namely, single-molecular studies, photonics, plasmonics, synthetic biology, and healthcare.
In this work, I will highlight the state-of-the-art in the field of DNA
nanotechnology with a focus on DNA self-assembly guided bottom up
patterning of inorganic nanoparticles. Following that I will briefly
talk about some of our ongoing endeavors in leveraging different DNA
nanostructures as vehicles for assembling three candidate particles
with nanometer precision, namely, DNA triangles with gold nanorods for
the realization of architectures with interesting plasmonic properties,
DNA icosahedra with quantum dots (QD) for enhancing control over
downstream QD fluorescence-based applications, and DNA
“bricks” with fluorescent molecules such as Cyanine dyes for expanding our
understanding of long range energy transfer reactions.