The Chandra exposure on the Chandra Deep Field-South (CDF-S) has recently been increased to 7 Ms, making it the most sensitive extragalactic X-ray survey by a wide margin. About 1050 X-ray sources have been detected, primarily distant active galactic nuclei (AGNs) and starburst/normal galaxies. The unmatched deep multiwavelength coverage for these sources allows superb follow-up investigations, revealing the details of supermassive black hole growth over most of cosmic time. I will briefly describe the sources in the 7 Ms CDF-S and some exciting first science results. The latter will include (1) relations between black-hole growth and host stellar mass; (2) constraints on supermassive black hole growth in the first galaxies as revealed by direct detection and stacking; and (3) the discovery of a representative of a new population of faint, fast X-ray transient sources. Finally, I will discuss some future prospects for X-ray surveys of AGNs in the distant universe.